Exactly where we have ended up..
This reflects our experience and is exactly where we have arrived. Our stack looks like this
ESXi Hosts
Hybrid iSCSI SAN
Disk to Disk Backup with Deduplication
Disk to Cloud Backup for archiving (Documents, call recordings etc to Glacier)
Disk to Tape Backup for DR (Virtual Machine images etc)
Coming up with a strategy for Cloud Backup was quite difficult for us, in the end we decided it only had 1 benefit which is long term storage of cold data at a reasonable price. Cost wise, we have been very pleasantly surprised, we uploaded about 3TB of data (consisting of around 700k files) and the total for the month was about £20.. I would never use this for DR purposes, as we calculated this would cost a small fortune to recovery a large volume of data in a short period.
"Suppliers like Nasuni say the cloud can be used for primary storage with local caching appliances."
Maybe for the "junk" fileshares where all the crap accumulates - but unless they have a 100% uptime grantee and compensation scheme to cover company costs and lost revenue, forget it!